Best in 7 days
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Ships within 48 hours · Estimated delivery Oct 12 - Oct 17
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Description
Cyclopamine, >99%Cyclopamine inhibits the Hedgehog signaling pathway with an IC50 of 46 nM, and blocks the activity of human Smo receptor expressed in CHO K1 cells in [3H]Hh Ag binding assay with an IC50 of 280 nM. Cyclopamine significantly inhibits Hedgehog pathway activity in a dose dependent manner in gut derived tumor cell lines expressing Patched (PTCH) mRNA, and induces growth inhibition of those tumor cell lines by 75 95% at the concentration of 3 M, but
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Exchange/Return Notes
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.6 ★★★★★
Based on 794 reviews
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Product Reviews
★★★★★ 5
Teething proof!
Color: bone, Size: 1 Count (Pack of 1)
My 9 month old mini dachshund loves this bone. Holds up impeccably. Great price. Thank you Kong!
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Reviewed in the United States on February 25, 2026
★★★★★ 5
Nice
Color: bone, Size: 1 Count (Pack of 1)
Nice
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Reviewed in the United States on June 8, 2026
★★★★★ 5
Great for Puppies
Color: bone, Size: 1 Count (Pack of 1)
Yes, my puppy loves it.
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Reviewed in the United States on April 8, 2026
★★★★★ 3
Great for Small-Medium dog
Color: Pink, Size: Small (Pack of 1)
Treat hole very small could be larger, excellent for small or medium dog!
Filled with peanut butter and froze them; keeps pup busy!
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Reviewed in the United States on February 14, 2026
★★★★★ 5
Great for dogs that chews a lot up everything
Size: Medium (Pack of 1)
Great for a puppy (large puppy) that chews a lot! So far, this toy is indestructible - and is the first toy she hasn’t chewed into bite size pieces! She loves to play with it all the time.
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Reviewed in the United States on May 17, 2026
